The tomato variety ‘Yingshi Dahong’ was used as the material to carry out the cultivation experiment in the greenhouse under drip irrigation and fertilization conditions; The upper limit of irrigation is set at three levels, that is, the relative water content of the soil is 70% (W₁), 80% (W₂), and 90% (W₃) of the maximum water holding capacity in the field, respectively, and the lower irrigation limit is uniformly set to 50% of the maximum water holding capacity in the field. N, P, K fertilization set three levels, low fertility F₁ ［N (228 kg/hm²), P₂O₅ (132 kg/hm²), K₂O (300 kg/hm²)］, medium fertilizer F₂ ［N (285 kg/hm²), P₂O₅ (165 kg/hm²), K₂O (375 kg/hm²)］ and highfertilizer F₃ ［N (342 kg/hm²), P₂O₅ (198 kg/hm²), K₂O (450 kg/hm²)］, with flood irrigation large water (8 165 m³/hm²) and local recommended fertilization amount (342 kg/hm² N, 198 kg/hm² P₂O₅, 450 kg/hm² K₂O) as common waterfertilizer control (CK). To explore the effects of different irrigation upper limit and fertilization treatment combinations on tomato yield quality and dry matter quality, in order to screen the optimal irrigation limit and fertilization amount of tomato cultivation in greenhouse. The results showed that: (1) Under the condition of integrated water and fertilizer, the dry weight of the above ground parts of the tomato plants, the dry weight of the shoots, and the rootshoot ratio were significantly higher than those of the traditional water and fertilizer treatments except F₃W₁. (2) The yield of tomato fruit was different under different irrigation upper limits and fertilization amounts. Among them, the fruit weight, economic yield and biological yield of tomato fruit reached the highest under F₂W₂ treatment, and the difference was significant with CK. (3) Under the same irrigation limit, increasing the amount of fertilizer in a certain range can significantly increase the content of soluble sugar, vitamin C, soluble protein and lycopene in tomato fruit. However, the organic acid and nitrate contents of tomato fruit increased with the increase of fertilizer application; Under the same fertilization amount, the organic acid content of tomato fruit decreased with the upper limit of irrigation, while the nitrate content of tomato fruit increased with the upper limit of irrigation. The study found that under the condition of drip irrigation and fertilization, the irrigation amount and fertilization amount of greenhouse tomato can significantly increase the yield of tomato and the contents of soluble sugar, vitamin C, soluble protein, lycopene and organic acid in tomato fruit, reduce the nitrate content and increase the accumulation of dry matter. The best water and fertilizer treatment combination is the upper limit of irrigation with 80% of the maximum water holding capacity in the field, the irrigation amount with 3 686.691 m³/hm², the fertilization amount is 285 kg/hm² N, 165 kg/hm² P₂O₅, 375 kg/hm² K₂O. The tomato yield increased significantly by 15.03% compared with the traditional water and fertilizer treatment, and the fruit quality was also effectively improved.