The purpose of this paper is to study the expression and function of VqSTS21,VqSTS30 and VqSTS32 genes,which cloned from powdery mildew-resistant Chinese wild Vitis quinquangularis accession ‘Danfeng-2’.Sequence analysis indicated that their cDNA has equal length of 1 179 bp and encodes 392 amino acid residues (GenBank accession No.JQ868677,JQ868668 and JQ868666).qRT-PCR showed the expression patterns of VqSTS21,VqSTS30 and VqSTS32 in ‘Danfeng-2’ and powdery mildew-susceptible Cabernet Sauvignon (Vitis vinifera L.) under biotic stress (Uncinula necator) and abiotic stress (ABA,SA,MeJA,heat,low temperature and NaCl).HPLC was employed to analysis resveratrol contents of these three genes overexpressed in transgenic tobacco plants.The results showed that the expression of VqSTS32 was higher than that of other two genes in two grape germplasms tested after treated with biotic stress and heat.Compared with the VqSTS21 and VqSTS30-overexpressed lines,trans-resveratrol was the highest accumulation in the VqSTS32-overexpressed lines of transgenic tobacco plants.Our results suggested that VqSTS32 gene was involved in the resveratrol synthesis pathway in grapes,and played an important role in response to U.necator.