Pennisetum sinese has become a prospective material for phytoremediation of heavy metal pollution, because of its advantages of rapid growth and large biomass. Drought is the main factor that affects its growth and phytoremediation ability. A pot experiment was conducted to study the effects of drought treatment (25% FC), Cd treatment (3 mg·kg^-1) and its interaction treatment on growth, photosynthesis, content of reactive oxygen species, antioxidant enzyme activity, Cd accumulation and distribution characteristics of P. sinese. Results showed that： （1） the biomass accumulation and photosynthetic activity of P. sinese were significantly inhibited by drought treatment, Cd treatment and interaction treatment, but the tolerance coefficient of P. sinese was relatively high under these treatments when compared to the controls. The MDA content and the POD and CAT activities in leaves increased to a certain degree under these treatments, while the activity of APX increased significantly only under interaction treatment. Both Cd treatment and interaction treatment induced significant reduction of SOD activity. （2） In terms of biomass accumulation and membrane damage caused by reactive oxygen species (represented by MDA), interaction treatment did not cause more serious negative effects than any single treatment. （3） Under the Cd treatment and interaction treatment, the content of Cd in all the organs of P. sinese increased significantly, and was mainly distributed and accumulated in roots. Though the interaction treatment significantly reduced the Cd concentration in P. sinese, it did not reduce the Cd concentration in shoots significantly. Above results suggested that P. sinese have strong tolerance to drought and Cd pollution, and interaction treatment would not cause more serious adverse defects, but would significantly reduce the Cd concentration in roots of P. sinese. Therefore, planting P. sinese in the area affected by both drought and Cd pollution might obtain a prospective phytoremediation effect.