With‘Zhugenjiang’ ginger (Zingiber officinale Roscoe) as the object of study,we analyzed the physiological and biochemical mechanism of MeJA induced to the disease resistance.The research discovered that the treatment of exogenous Methyl jasmonate(MeJA) could significantly reduce disease indices of ‘Zhugenjiang’ ginger,and increase resistance against Bacterial Wilt of Ginger.no directly inhibitory effect was detected on pathogenicity of Ralstonia solanacearum in vitro.MeJA-treated ‘Zhugenjiang’ ginger could speedly promote endogenous H₂O₂ content during the early stage,and simultaneously induce the increases of activities of phenylalanine ammonialyase(PAL),peroxidase(POD),polyphenol oxidase(PPO),catalase(CAT),chitinase and β-1,3-glucanase associated with increase of lignin content.The results exhibited that MeJA regulated the downstream signaling molecule H₂O₂ level to enhance activities of enzymes related to defense and expressions of pathogenesis-related proteins(PR proteins) in ginger cells,resulting in promoting lignin accumulation and furthermore improving disease resistance in ginger.