The ‘Bayuehong’ and ‘Hongxiangsu’ were taken as materials to study the changes of coloration,composition and content of anthocyanin,and related enzymes in sand pear (Pyrus pyrifolia) fruit skin under different cultivated regions and years.The result showed that:(1)The change rules of anthocyanin in ‘Bayuehong’ and ‘Hongxiangsu’ skin decided by the characteristics of cultivar,different cultivated region and years affected the absolute content of anthocyanin in the same cultivar,they could’t affect change trends of the composition and content of anthocyanin.However,the different change patterns and anthocyanin content observed in different cultivars.(2)The variation of skin color in red pear was consistent with the changes of cornflower-3-galactosidae content.The activities of UFGT(UDP-glucose:flavonoid 3-O-glucosyltransferase) and DFR(dihydroflavonol-4-reductase) increased with the fruit development and color deepenning,while the acitivity of PAL(phenylalanin ammonia lyase) decreased with the fruit development.(3)The correlation analysis revealed that a significant or very significant positive correlation between the content of anthocyanin and the activities of UFGT and DFR,wherease showed different correlation with PAL in different cultivars.The results indicated that UFGT and DFR are the important enzymes,which affect the coloration of red-skin sand pear.