The pre-screening Cu-enrichment plant Myriophyllum aquaticum had been used as the experiment material.Through two factor randomized block experiment design,the antioxidant enzyme activity of M.aquaticum under different concentrations of Cu and Zn contaminated soil had been conducted by pot experiment.The results indicated that:(1)Under different concentrations of Cu and Zn compound pollution,the biomass of M.aquaticum was promoted by the low concentration pollution and inhibited by the high concentration pollution.(2)Under different concentrations of Cu and Zn compound pollution,the MDA content of M.aquaticum with the increase of Cu-Zn concentration showed after the first rise to reduce.(3)Different concentrations of Cu and Zn compound pollution played different roles on the activity of antioxidant enzyme system of M.aquaticum.The low concentration of Cu and Zn compound pollution improved the activities of SOD,POD and CAT,while the increased concentration of Cu and Zn compound pollution showed different effects on the activities of SOD,POD and CAT.Based on the data reported,under the pressure of the combination of Cu and Zn,M.aquaticum cell activate the emergency defense system,then SOD,POD and CAT start to work to removal of excess free radicals in the body in time,so that maintain the high tolerance of M.aquaticum under the stress of Cu and Zn.It is possible that M.aquaticum is a new material of ecological restoration and reconstruction of vegetation in Luxi river and other similar rivers contaminated by Cu and Zn.