In the process of plantpathogens interaction, a series of signal transduction and defense system are excited in plant, which triggers rapid and effective defense responses. After activation of defense responses, will cause synthesizing and accumulating of a series of exogenous signaling molecules. The plant hormones salicylic acid (SA), jasmonic acid (JA) and ethylene (ET) are recognized as key players in the regulation of the signaling pathways involved. In this review, the recent research advances on the interaction among the three different signaling pathways are summarized. It also presented the function of several key regulatory proteins such as NPR1，EDS1，MPK4, which are known to play important role in SA and JA/ET signaling cross talk and coordinating their complex relationships. In addition, the prospect of future work is discussed in the review.