Growth, physiological, and biochemical attributes of Fuzhou Yuhu were studied under red and blue LED light with different intensities and ratio with fluorescent lamp (CK) as a control in a closed lighting growth chamber within a plastic greenhouse in south China. Two different light qualities i.e., R∶B=7∶3 and R∶B=3∶7 with three different light intensities 50, 100, 120 μmol·m^-2·s^-1 were used in this study. The results showed that: (1) after 7 ~ 14 d treatment, chlorophylls a, b and total chlorophyll and carotenoid content increased with the increasing number of days. However, the index of each pigment declined in the later stage. (2) Under the same light intensity, the soluble sugar content at higher red light proportion was obviously higher than that at higher blue light proportion. However, the protein content in the seeding leaf at higher blue light was significantly higher than that in seeding leaf at higher red light. (3) With the increase of light intensity, gourd height, leaf area and other growth indicators had improved significantly，while the content of MDA decreased significantly. Hence, red and blue light 7:3 with 120 μmol·m^-2·s^-1 could better promote the growth, biomass and internal physiological indicators of gourd.