In order to clarify the information of CmTPS gene family and the patterns of response to environment cues, we identified seven TPSs in melon genome in this work. These TPSs distributed on seven chromosomes and designated CmTPS1-7. Phylogenetic analysis indicated that CmTPS genes would be classified into classⅠand classⅡ. CmTPS4 and CmTPS7 belong to classⅠwith 16 introns and their proteins probably possess TPS activity. The other five CmTPS genes, containing two to four introns, were classified into class Ⅱ. CmTPS3 consists of only TPS domain, whereas the remaining TPSs comprise TPS, TPP and UDPforming domains. CmTPS proteins have low similarity (15.90%-57.31%) within family members. Subcellular localization prediction indicated that CmTPS1, CmTPS2 and CmTPS6 were localized to the nucleus and the others in cytoplasm. The expression of CmTPS genes under various abiotic stresses showed that CmTPS4 might be main gene encoding TPS in melon leaves under low temperature stress, while melon TPS family genes were more sensitive to salt stress and might be involved in regulation of ABA signal pathway. Our results lay the foundation for functional characterization of melon TPS family genes in the future.