In this study, we used Vitis vinifera L. cv. Cabernet Sauvignon to study anthocyanins and resveratrol accumulation at maturity stage, expression of anthocyanins and resveratrol biosynthesis genes by using HPLC technology, pH differential method and realtime quantitative PCR. The study aims to reveal the regulatory mechanism of structural genes and to provide theoretical basis for screening grape wine rich in anthocyanins and resveratrol. The research findings suggested that: (1) the anthocyanins contents at 112 days after anthesis reached the maximum of 0.77 mg/g, the contents of transresveratrol at 126 days after anthesis reached the maximum of 30.87 μg/g. (2) The expression of CHSs, CHI, STS, UFGT, MybA1 and MybA2 genes in the pathway of anthocyanin and resveratrol synthesis were upregulated, but they were downregulated on 98 days after anthesis. (3) The correlation analysis showed that the expression of STS gene was the most significantly and significantly positively correlated with the expression of CHS1 and CHS2 genes. The expression of MybA1 and MybA2 genes was the most significantly positively correlated with the expression of CHSs, CHI, STS and UFGT genes, and the expression of Myb5a gene was significantly positively correlated with the expression of CHS3 gene. The research showed that the expression of some structural genes was not synchronized with the accumulation of anthocyanins and resveratrol. MybA1 and MybA2 may express multiple structural gene regulation of anthocyanins synthesis pathway. The relationship between anthocyanins and resveratrol was not fixed, but in a dynamic change.