Two species, Orthotrichum pamiricum and O. scanicum, are reported from Xingjiang in the study. Among them, O. pamiricum has obtuse apex of leaves, stomtata immersed, at below the middle part of urn, outer layer of eight pairs of teeth reflexed when dry; and inner peristome segments 16. On the other hand, the main characters of O. scanicum has crenulate leaf apex, stomata semiimmersed, calyptra with a few hyaline hairs, and both peristome teeth and peristome segments 16, with 8 fine furrows. The morphological characters, habitat and geographical distribution, and morphological comparison with related species of them are discussed. The illustrations of each species are provided. The distribution of the two new species in China of Orthotrichum further indicates the rich biodiversity of Xingjiang, China, as well as the close bryoflora relationships between Xingjiang and Central Asia.