DELLA protein, a transcription factor that plays an inhibitory role in the GA signal transduction pathway, is a type of growth inhibitory protein that localized in the nucleus and can directly interact with proteins of key transcription factors in plants, thereby playing a central role in many plant signaling activities. This paper summarizes the identification, temporal and spatial expression patterns, molecular structure, regulatory mechanisms in GA signal transduction, interaction with PIF and Fbox protein of DELLA protein gene family and the role of DELLA protein in seed germination, morphogenesis, rhizobial symbiosis of legumes, stomatal closure, plant stress response and so forth of several fruit trees, vegetables, flowers, model plants, grain crops, and so forth at home and abroad in recent years, and the difference of DELLA protein gene family between these species are also compared. Finally, we prospected its future research hotspots and directions, to provide information for further exploration of the function of DELLA protein.