In order to reveal the function of WRKY gene in pepper, we cloned the fulllength 1 647 bp cDNA of WRKY gene from pepper PI201234 and named as CaWRKY8. Bioinformatics analysis indicated that the gene contains a 1 647 bp complete open reading frame (ORF) box encoding 548 amino acid residues. Amino acid sequence analysis revealed that the CaWRKY8 encoded protein contains two WRKY domains belonging to Group I. The amino acid sequence alignment showed that there was a high degree of conservation between CaWRKY8 and the amino acid sequences of pepper WRKY25, potato WRKY, tomato predicted WRKY26, tobacco predicted WRKY33 and kiwi WRKY. Realtime fluorescence quantitative analysis showed that CaWRKY8 was induced by salt, high temperature, drought and Phytophthora capsici, and CaWRKY8 peaked at 3 h under salt and drought treatments by 2.38 and 121.10 times of control, respectively. Under high temperature and P. capsici treatment, the peak reached at 12 h, which was 6.12 and 6.81 times of the control, respectively. The above results indicate that CaWRKY8 played an important role in the response of pepper to stress.