As a major environment factor, low temperature affects the geographic distribution and diversity of plants, and threats the sustainable development of agriculture. ICE1 (INDUCER OF CBF EXPRESSION1)CBF (CREPEATBINDING FACTOR) signal pathway functions critical roles not only in plant cold tolerance, but also in plant growth and development. The insight into ICE1CBF pathway improves our understanding about how plants balance growth and cold tolerance. In this review, we summarized the latest advances in research of the sophisticated regulation of ICE1CBF pathway in cold tolerance, and mainly discussed the roles of ICE1CBF pathway in plant growth and development.