Based on field investigation and relevant literatures, this study has comprehensively analyzed and discussed the characteristics of the seed plants flora in Dehang Scenic spot from the aspects of family, genus and species. Meanwhile, we revealed the nature and status of the flora via comparison between plants grown in different special ecoenvironment types and those grown in adjacent regions. The results provide an important basis for management and sustainable utilization of natural resources in Dehang Scenic spot. The results showed that: (1) there was high species diversity of Spermatophyta in Dehang. Our investigation showed that there were 1 626 species of wild seed plants belonging to 154 families, 710 genera. These plants accounted for 94.48%, 83.43% and 54.00% of seed plants families, genera and species in the Wuling mountain area, and for 73.33%, 54.20% and 33.46% in Hunan Province. (2) The floristic analysis showed that the geographical element of seed plants in Dehang was complex. There are 12 areatypes of families, 14 areatypes of genera, and 15 areatypes of species in this area. The areatype of families and genera was mostly pantropic. For species, the number of endemic to China was the largest. Meanwhile, the flora of Dehang exhibited obvious endemism. The area contained 7 endemic families in East Asia, 2 Chinese endemic families, 27 Chinese endemic genera, and 588 Chinese endemic species, including 39 endemic species in central China, 29 endemic species in the Wulingshan region, and 6 endemic species in Dehang. (3) The floristic components of this area differentiated with different habitats. There were obvious differences in floristic components among three representative habitats: platform, cliff and valley. The flora of Dehang were similar to the neighboring Huping Mountain, Xiaoxi and Oolong Mountain. Overall, the flora of seed plants in Dehang Scenic spot has the characteristics of East Asian flora, and it has an important place in the flora of the Wulingshan region.