In order to identify the dehydration responsive element binding (DREB) genes in response to salt stress from the genomewide and transcriptome levels in wheat, this study performed transcriptome sequencing on the Illumina platform for roots of a salttolerant material CH7034 treated with salt stress at seedling stage, from which information on expression and alternative splicing of the TaDREB family were isolated and their downstream target genes were predicted. Finally, the TaDREBs and predicted targets in response to salt stress were verified by qRTPCR. The results showed that: (1) 48 DREB members (204 copies) named TaDREB1-TaDREB48 were identified in wheat and distributed on 21 chromosomes. (2) The TaDREB family was divided into 14 groups (G1-G14). The transcription levels of TaDREB members belonging to G2, G5, G10 and G14 did not change significantly after NaCl stress, while 25 TaDREB members from the rest of the groups showed different degrees of response to salt stress. Among them, 9 members were continuously upregulated after salt stress (containing 5 new reporter genes), and 2 members were continuously downregulated. The protein encoded by the downregulated member TaDREB35 might be degraded by a wheat RINGtype E3 ubiquitin ligase based on the protein interaction prediction result. (3) 9 members, including TaDREB3, TaDREB6, TaDREB16, TaDREB19, TaDREB21, TaDREB24, TaDREB25.12, TaDREB43 and TaDREB47, underwent alternative splicing changes after salt stress. (4) Based on the transcriptome, 3 differentially expressed genes TaRD29, TaGLOS and TaCKX with DRE/CRT elements in 2 000 bp region upstream of their start codon and the same expression trend between A/B/D subgenomes were selected as candidate targets. (5) qRTPCR verification results showed that the expression levels of TaDREB16 and the upregulated members except TaDREB19 displayed continuous upward trend; only TaDREB25 and TaDREB35 among the downregulated members displayed continuous downward trend; and the expression levels of the three predicted target genes continued to increase, which was consistent with the transcriptome sequencing results. The 11 salt stressresponsive TaDREB members and the 3 predicted targets identified in this study will lay the groundwork for the analysis of the salt tolerance mechanism and molecular breeding in wheat.