Leaf senescence is an important developmental process involving orderly disassembly of macromolecules for relocating nutrients from leaves to other developing organs and is critical for plant survival and adaptation. Leaf senescence is primarily regulated by plant development, but is also influenced by internal and external environmental factors. Leaf senescence involves highly intricate regulatory networks and multilayered regulatory mechanisms. Recent studies had shown that epigenetics was an important mode of regulation of leaf senescence in plants. This review provided an overview of the known epigenetic regulation of plant leaf senescence, including histone modifications, DNA methylation modification, ATP-dependent chromatin remodeling and non-coding RNA mediated regulation. The future research trends in this area were also prospected.