In this study,a saltinduced MYB transcription factor gene,TaSIM,was isolated from cDNAs library of wheat leaves under salt stress.The full length TaSIM cDNA is 1 213 bp,including an ORF of 831 bp.This cDNA sequence encoded a polypepide of 276 amino acid residues with a predicted molecular mass of 29.903 kD and a basic isoelectric point of 10.12,and two highly conserved SANT domain in the encoded putative protein.The phylogenetic analysis showed that TaSIM has the highest similarity with XP_003576185 from Brachypodium distachyon.Semiquantitative RTPCR analysis revealed that TaSIM gene was obviously induced by salt stress.Subcellular localization assay indicated the TaSIMhGFP fusion protein was located in the nucleus.The results suggested that TaSIM transcription factor might be involved in salt stress response of wheat.